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Journal of Aging and Health
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Medication Adherence in Healthy Elders

Small Cognitive Changes Make a Big Difference

Tamara L. Hayes, PhD

Oregon Health & Sciences University, Portland, hayesta{at}ohsu.edu

Nicole Larimer, BA

Oregon Health & Sciences University, Portland

Andre Adami, PhD

Universidade de Caxias do Sul, Brazil

Jeffrey A. Kaye, MD

Oregon Health & Sciences University, Portland

Objective: This was a cross-sectional study of the ability of independently living healthy elders to follow a medication regimen. Participants were divided into a group with High Cognitive Function (HCF) or Low Cognitive Function (LCF) based on their scores on the ADAS-Cog. Method: Thirty-eight participants aged 65 or older and living independently in the community followed a twice-daily vitamin C regimen for 5 weeks. Adherence was measured using an electronic 7-day pillbox. Results: The LCF group had significantly poorer total adherence than the HCF group (LCF: 63.9 ± 11.2%, HCF: 86.8 ± 4.3%, t 36 = 2.57, p = .007), and there was a 4.1 relative risk of non-adherence in the LCF group as compared to the HCF group. Discussion: This study has important implications for the conduct of clinical drug trials, as it provides strong evidence that even very mild cognitive impairment in healthy elderly has a detrimental impact on medication adherence.

Key Words: cognitive impairment • medication • adherence

This version was published on June 1, 2009

Journal of Aging and Health, Vol. 21, No. 4, 567-580 (2009)
DOI: 10.1177/0898264309332836
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